It is also an excellent illustration of the benefits of
design of experiments
(DOE). By applying DOE in lab scale, the relevant information can be obtained using only a minimum of resources. Critical factors are identified, responses are efficiently optimized, and the robustness of the system can be explored.
The Fine Chemicals Business Unit of
LANXESS Deutschland GmbH
in Leverkusen, Germany, has chosen Umetrics software
MODDE
for their DOE work in process development. Read more at
LANXESS.
Another good example using DOE and
MODDE
in scale-up can be found in an article from Lonza Ltd. – "Synthetic Process Development and Scale-up of the Oxidative Cleavage of a Double Bond Catalyzed by Ruthenium Trichloride". An abstract can be found at
American Chemical Society.
Follow the instructions to download the full article (password from ACS is required).
